Investigating How Oxidative Stress Accelerates Telomere Loss: Implications for Cancer and Aging
This is a past event.
Friday, March 22, 2019 at 11:00am to 12:00pm
PG5 - Market Station, 134
11200 SW 8th ST 33199, PG5 - Market Station, Miami, Florida 33199
Join us for a talk with Dr. Patricia Opresko, Professor, Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health on “Investigating How Oxidative Stress Accelerates Telomere Loss: Implications for Cancer and Aging.” The seminar will take place on Friday, March 22, 2019 from 11:00 a.m. to 12:00 p.m. in PG5 134.
Telomeres at chromosome ends are essential for preserving genome stability and cellular proliferation, but telomeres shorten during aging with each cell division. Dysfunctional telomeres trigger 1) cell senescence which drives aging-related degenerative diseases, or 2) genomic alterations which promote carcinogenesis. Oxidative stress and reactive oxygen species (ROS) accelerate telomere shortening and loss, and are also implicated in aging and numerous degenerative diseases. The Opresko lab is investigating how oxidative stress leads to telomere loss and has developed novel approaches for determining how oxidative damage to telomeric DNA impacts telomere maintenance.