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Our group focuses on the tissue and cellular response to mechanical and chemical insults. Early work in our laboratory examined the effects of mechanical trauma on spinal cord function and physiology in conjunction with Purdue’s Center for Paralysis Research. The relatively simple geometry of the spinal cord white matter was a useful foundation for the development of our multiscale models linking cellular and tissue level damage. We are currently extending these investigations as part of the College of Engineering’s award-winning, multidisciplinary Purdue Neurotrauma Group (PNG) to better understand traumatic brain injury. This work led to the discovery that a substantial portion of football and soccer players exhibit neurophysiological trauma without readily identifiable symptoms. More recently, we have established that damage accumulates due to repeated head impacts and the amount of damage is related to the number, location, and magnitude of those blows. That realization provided the motivation for testing and evaluating modern helmets and designing new solutions for protecting the brain. Mitigating the effects of head injury requires better protective, diagnostic, and therapeutic interventions, all areas where Dr. Nauman and PNG are currently developing and patenting new technologies.

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